Humanin 10mg

R910,00

Humanin 10mg

Neuroprotection, Oxidative Stress, Toxicity, Inflammation, Metabolic Health, Insulin Sensitivity, Cardiovascular Health.

R910,00

Out of stock

How It Works

Think of Humanin as your mitochondria’s ’emergency SOS signal’ that protects cells under stress and promotes healthy aging.
How it works (super simple):
– Binds receptors (e.g., FPRL1, CNTFR/WSX-1/gp130) and directly inhibits pro-apoptotic proteins (Bax/Bid) at the mitochondrial membrane.
– Activates survival pathways (STAT3, ERK, AKT), reduces oxidative stress, and improves mitochondrial function/insulin sensitivity.

Possible Benefits

Main benefits (strongest from preclinical models and human correlations):
– Neuroprotection: shields neurons from amyloid-beta toxicity, oxidative stress, and inflammation; potential in Alzheimer’s, Parkinson’s, and stroke models.
– Metabolic health & insulin sensitivity: improves glucose metabolism, reduces body weight gain in obesity/PCOS models, and enhances exercise adaptations.
– Longevity & health span: correlates with longer lifespan in mice; analogs extend median lifespan and reduce inflammation in midlife treatment studies.
– Bonus signals: cardio protection, anti-inflammatory effects, and support for reproductive/ovarian health in aging models.
In short: It helps cells survive stress and age more gracefully by optimizing mitochondrial signaling – one of the most promising MDPs for anti-aging research.

Reconstitution, Dosage and Cycling

Reconstitution, dosage and cycling protocols for research purposes.

Method of Administration: Subcutaneous into fatty tissue.

Reconstitution: 2ml Bac water into single vial. See Reconstitution Guide

Dose: 2mg daily, therefore 20 units or 0.2ml. Use peptide calculator (link) for alternative dosage.

Course: 20 days.

Cycling: Repeat every 3 months for maintenance or as needed (e.g., during respiratory seasons or after illness).

Fun Facts you Should Read

Mitochondrial messenger – the first discovered MDP (mitochondrial-derived peptide); encoded in mtDNA and signals to the nucleus during stress.
Alzheimer’s discovery – found while hunting for factors that protect surviving brain cells in Alzheimer’s patients.
Lifespan link – higher natural levels correlate with longer life in mice; midlife treatment with analog HNG extends health span.
24-amino-acid mini-protein – small but mighty; a potent analog (HNG/S14G) is 1,000× stronger than natural Humanin.
Insulin sensitizer – improves glucose metabolism and exercise adaptations without the downsides of full growth hormone.
Sex-specific nuances – effects can differ between males and females in some models.
Research rising star – still actively studied in 2026 for neurodegeneration, metabolism, and healthy aging.

Citations and Sources

Human data is mostly correlative (levels in aging/AD); strongest evidence is preclinical (mice, cells) with promising longevity/metabolic signals.
1. Coradduzza et al. (2023 PMC): Comprehensive review – Humanin improves glucose/insulin sensitivity in animal models; links to aging, metabolism, and cytoprotection.
2. The Peptide Catalog (Feb 2026): Dosing guide 100300 mcg research range; mechanisms (Bax/Bid inhibition, STAT3 activation); longevity protocols.
3. Swolverine (Jul 2025): Beginner guide – neuroprotective, metabolic, and anti-aging benefits; safe endogenous peptide.
4. ScienceDirect overview: Protective effects in neurons, leukocytes, gonadal cells; stress resistance and potential in neurodegeneration.
5. Peptide Calculator App (Dec 2025): Dosage/mechanism – insulin sensitivity, neuroprotection; 1001000 mcg ranges in research.
6. Yen et al. (2013 PMC): Emerging role in stress resistance; cytoprotective against oxidative stress, hypoxia, etc.
7. Aging-US (Jun 2020): Humanin regulates lifespan/healthspan in mice; midlife HNG treatment improves metabolic parameters and reduces inflammation.
8. Paragon Sports Medicine (2026): Energy & healthy aging mitochondrial optimization, cellular protection; research-only status.
9. Alzheimers Drug Discovery Foundation (updated references): Evidence summary – neuroprotective in AD models; insulin sensitivity and healthspan benefits; no human therapeutic trials yet.
10. ResearchGate / lifespan study (Dec 2025 update): Midlife HNG extends healthspan and lifespan in mice; first demonstration of MDP regulating longevity.

Takeaway: Strong preclinical longevity/neuroprotection data + human correlations; we need large clinical trials for therapeutic validation.

Dislaimer

Important disclaimer upfront: Humanin is NOT approved by the FDA (or any major Western agency) as of 2026. It remains strictly investigational/research chemical in the US (compounded versions face restrictions under 2026 peptide rules). It is approved and widely used in Russia as a prescription medication for immune restoration. Long-term safety data in healthy Western populations is limited. It is banned by WADA. Always talk to a doctor – this is not medical advice.

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