R950,00
Accelerated Muscle Growth, Hyperplasia, Joint Health, Enhanced Recovery, Body Composition, Sleep Enhancement and Anti-Aging.
R950,00
Out of stock
IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3) is a lab-made synthetic analog of natural IGF-1 – a modified 83-amino-acid protein engineered with two key changes: an arginine substitution at position 3 and a 13-amino-acid extension at the N-terminus (the ‘Long’). These tweaks make it far more potent and longer-lasting (half-life ~20-30 hours vs ~10-20 minutes for native IGF-1) by preventing it from binding to IGF-binding proteins that normally deactivate it. It was developed in the 1990s-2000s as a research tool to amplify the muscle-building and fat-burning effects of IGF-1 (the main mediator of growth hormone) without raising blood sugar or promoting unwanted organ growth as strongly as full GH.
Think of IGF-1 LR3 as ‘supercharged muscle fertilizer.’ It acts directly on muscle cells to drive growth and repair far more potently than natural IGF-1.
How it works
-Binds IGF-1 receptors (and to a lesser extent insulin receptors) on muscle and other tissues.
-Triggers hyperplasia (increases the actual number of muscle cells) + hypertrophy (makes existing cells bigger) via enhanced protein synthesis, nutrient uptake, and satellite-cell activation.
IGF-1 LR3 has a relatively clean short-term profile in available data, but its potency means risks are higher than milder peptides.
In research and user reports: Mostly dose-dependent and manageable.
Common/mild:
– Hypoglycemia (low blood sugar) – monitor carbs; can cause shakiness or fatigue.
– Injection-site irritation or water retention.
– Joint pain, lethargy, or mild insulin resistance with prolonged/high use.
No official guidelines (not approved), so these come from research protocols and common clinic/anecdotal use.
Method of Administration: Subcutaneous into fatty tissue.
Reconstitution: 2ml Bac water into single vial. See Reconstitution Guide.
Dose: 50-100mcg daily, therefore 10-20 units or 0.1ml -0.2ml. Use peptide calculator for alternative dosage.
Course: 10-20days depending.
Some protocols go up to 100-200 mcg for short periods but start low (20-40 mcg) to assess tolerance.
Cycling:
4-6 weeks on, then 4-6 weeks off (to avoid desensitization or receptor downregulation).
Often used in short ‘blast’ phases aligned with training blocks or injury rehab.
Tip: Reconstitute with bacteriostatic water; store in fridge. Use insulin syringes and sterile technique. Post-workout timing maximizes muscle-specific effects.
Human data is limited (mostly early/small trials + preclinical); no large modern RCTs or approval path.
1. Anderson Longevity Clinic guide (20252026): IGF-1 LR3 mechanism via IGF-1R binding; promotes hyperplasia/mitogenesis for muscle growth.
2. Hubmeded review (Nov 2025): Modified analog with 20-30 hour half-life; benefits for muscle, fat loss, skin; not FDA-approved.
3. Swolverine IGF-1 LR3 guide (Jul 2025): Enhances protein synthesis, fat metabolism, recovery; research-only with 20-100 mcg dosing.
4. Revolution Health peptide overview (May 2025): Potent for muscle repair/fat loss; investigational with hypoglycemia risk.
5. WADA Prohibited List (2026): IGF-1 and analogs explicitly banned (S2.3 growth factors).
6. Peptide Initiative research summary (2026): 83-amino-acid structure with Arg3 + N-terminal extension; longer action than native IGF-1.
7. Medical Anti-Aging review (2024-2026): Therapeutic potential but gaps in long-term human safety/efficacy data.
8. Core Medical Group guide (2026): Nitrogen retention and muscle mass gains; research chemical status.
9. Supplement Warehouse analysis (Jul 2025): Hype vs science muscle growth/fat loss benefits but reconsider due to risks.
10. Beverly Hills Rejuvenation (Jan 2026): Anabolic effects in research settings; not FDA-approved.
Takeaway: Strong mechanistic/animal data for muscle growth; human evidence is anecdotal/limited far from approved status.
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All products are sold in powder (lyophilized) form and require reconstitution with a suitable diluent for research purposes only. Research supplies (e.g., syringes, bacteriostatic water) are not included and need to be purchased separately. No personal human dosing instructions are provided, only research dosages from clinical studies. We adhere to all local and national (SAHPRA) laws around Research Only Chemical sales. We are not a pharmacy, nor do we promote or provide any advice for human or animal consumption. Please review our terms and conditions carefully before making a purchase on our website.
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