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NAD+ injection (Nicotinamide Adenine Dinucleotide) is a lab-compounded form of the essential coenzyme your body naturally makes in every single cell. It is not a peptide or hormone, it is a tiny molecule (made from vitamin B3) that acts like a cellular ‘power adapter,’ shuttling electrons to turn food into energy (ATP) while powering DNA repair, gene regulation, and inflammation control. Levels drop sharply with age, stress, poor sleep, or alcohol – so direct injections (subcutaneous, intramuscular, or IV) deliver it straight into the bloodstream for rapid, noticeable replenishment.
Think of NAD+ as your cells’ ‘universal battery charger.’ When levels are high, everything runs smoother; when low, energy crashes and aging speeds up.
How it works (super simple):
– Fuels mitochondria to make ATP (energy).
– Activates sirtuins (longevity proteins that repair DNA and reduce inflammation).
– Powers PARP enzymes for DNA repair and CD38 for immune balance.
– Shifts metabolism toward fat-burning and better insulin sensitivity.
NAD+ injections are generally well-tolerated when dosed and infused slowly, but they’re not side-effect-free.
Common (especially during/after IV or higher doses):
– Flushing, warmth, or ‘niacin-like’ rush.
– Nausea, chest tightness, headache, or fatigue.
– Injection-site redness, swelling, or mild pain.
Less common (FDA-noted from compounded products):
– Chills, shaking, vomiting (usually if infused too fast or product quality issues).
Bigger caveats:
– Unknown long-term effects – almost no large, extended human studies on repeated injections.
– Not for pregnancy, breastfeeding, or certain active cancers (theoretical).
Bottom line: Most people feel fine after the first few sessions (discomfort often eases with slower administration), but quality sourcing and medical oversight are critical.
No official FDA guidelines exist – protocols come from clinics, compounding pharmacies, and small studies.
Reconstitute 5ml bac water into 1000mg vial.
Typical dose (subcutaneous or intramuscular injection – belly or thigh.
SubQ/IM: Start at 50 mg per injection. Therefore draw 25 units of a 1ml syringe. (.25ml). This will give you 20 doses (7 weeks)
Titrate up if necessary. See peptide calculator.
– Frequency: Daily or 2-3 times per week.
Cycling:
Tip: Reconstitute lyophilized powder with sterile water. Store in fridge. SubQ is easiest for at-home use; always sterile technique.
Human data for direct NAD+ injections is limited (mostly small pilots, case studies, and tolerability data); far more evidence exists for oral precursors like NR or NMN. Here are the key ones:
1. Reyna et al. (2026) Frontiers in Aging: Retrospective pilot comparing IV NAD+ vs NR infusions – good tolerability, safety markers, and metabolic signals in real-world setting.
2. FDA (2024) compounding safety alert: Adverse events (chills, vomiting, fatigue) reported with some NAD+ injectable drugs; reminds compounders of sterility rules.
3. Conlon et al. (2021, updated reviews through 2026): NAD+ role in regenerative medicine, aging, and disease – foundational mechanisms and early human signals.
4. Freeberg et al. (2023 PMC, with 20252026 follow-ups): NAD+-boosting compounds (including injectable context) raise NAD+ levels safely; dosing and tolerability overview.
5. Yusri et al. (2025 PMC): NAD+ metabolism review – direct IV supplementation raises levels in healthy/elderly cohorts; anti-aging and metabolic potential.
6. Mestayer/Parkinson’s case series (historical + 2025 references): IV NAD+ reduced tremors and symptoms in small observational reports; addiction recovery pioneer data.
7. Khatri et al. (2025) Geromedicine: Clinical evidence for NAD+ precursors in aging notes limited but promising injectable data alongside oral.
8. Empower Pharmacy & compounding reviews (2026): NAD+ injection (lyophilized) safety profile low incidence of serious effects when properly prepared.
9. Verywell Health / systematic reviews (2025-2026): NAD+ infusions not FDA-approved; benefits not firmly established in large trials; mixed metabolic outcomes.
10. Abdellatif et al. (2021 Circulation, cited through 2026): NAD+ in cardiac health & aging decline with age; replenishment benefits in models (context for injectable use).
Takeaway: Exciting mechanistic and small-human data, but we still need big randomized trials specifically on injections for firm conclusions.
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| Strength | 1000mg, 500mg |
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| Strength | 1000mg, 500mg |
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All products are sold in powder (lyophilized) form and require reconstitution with a suitable diluent for research purposes only. Research supplies (e.g., syringes, bacteriostatic water) are not included and need to be purchased separately. No personal human dosing instructions are provided, only research dosages from clinical studies. We adhere to all local and national (SAHPRA) laws around Research Only Chemical sales. We are not a pharmacy, nor do we promote or provide any advice for human or animal consumption. Please review our terms and conditions carefully before making a purchase on our website.
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