SS-31 50mg

R1 690,00

SS-31 50mg

Mitochondrial Repair and Energy Booster, Muscle Strength, Endurance, Heart Function, Neuroprotection.

R1 690,00

5 in stock

What It Is?

SS-31 is a lab-made synthetic tetrapeptide – a tiny chain of just 4 amino acids (D-Arg-2’,6’-dimethyl-Tyr-Lys-Phe-NH) designed to penetrate cells and selectively target the inner mitochondrial membrane.

Developed by Dr. Hazel Szeto at Cornell and advanced by Stealth BioTherapeutics, it ss the world’s first approved mitochondria-targeted therapy. Unlike most peptides we’ve covered, it is not a general ‘repair’ or hormone signal, it specifically protects and restores the cell’s power plants (mitochondria) by binding cardiolipin.

Think of SS-31 as a ‘mitochondrial bodyguard.’ It goes straight to the inner mitochondrial membrane and fixes the damage that causes energy failure.

How it works (super simple):

– Selectively binds cardiolipin (a key lipid in the inner membrane).
– Stabilizes electron transport chain supercomplexes, reduces harmful reactive oxygen species (ROS), prevents membrane leakage, and restores ATP production.

SS-31 has an excellent safety profile across trials, one of the cleanest mitochondria-targeted compounds tested.
In FDA approval data and long-term extension (TAZPOWER): Well-tolerated for years.
Most common (mild-moderate):
– Injection-site reactions (redness, itching, swelling, pain, most frequent but usually improve).
– Mild fatigue or headache (rare and transient).

– No major organ toxicity or serious systemic effects in studies.
– Accelerated approval means ongoing confirmatory trials are required.
– Theoretical hypersensitivity risk (rare).

Bottom line: Far safer than many experimental peptides, side effects are almost entirely local to the injection site.

Reconstitute 2ml bac water into 50mg SS31 Vial. See Reconstitution Guide

Dosage:

Daily 2mg. Draw 2ml of Bac water and reconstitute with 10mg vial. Draw 40 units on 1ml syringe and administer subcutaneously every morning. One vial lasts 5 days.

For the 50mg – 2ml bac water into vial. Draw 8 units daily. Should last 25 days.

Cycling: Do the above for 4 weeks 3 times a year.

  • World’s first mitochondria-targeted approved drug – September 2025 milestone after decades of development.
  • Cardiolipin superhero – it specifically hugs cardiolipin (the ‘glue’ of the inner mitochondrial membrane) to keep energy production running smoothly.
  • Tiny but targeted – only 4 amino acids, yet it concentrates 1,000-fold higher in mitochondria than in the rest of the cell.
  • Barth syndrome breakthrough – gave patients with this ultra-rare disease (only ~150-200 in the US) their first real treatment option.
  • Dr. Hazel Szeto’s legacy – invented at Cornell; she presented it as ‘the world’s first FDA-approved mitochondria-targeted drug’ at the 2025 Longevity Summit.
  • Long-term data hero – patients showed continued benefits out to 168+ weeks with almost no drop-off.
  • Not just for the sick – preclinical signals for aging, heart, kidney, brain, and eyes have longevity researchers excited.

SS-31 now has real FDA approval data plus long-term follow-up -stronger regulatory backing than most peptides.

1. FDA approval announcement (Sept 19, 2025): Accelerated approval for Barth syndrome 30 kg based on muscle strength improvements; first mitochondria-targeted drug.
2. Thompson et al. (2024, updated 2025) TAZPOWER 168-week OLE: Sustained muscle strength, cardiac function, and exercise capacity improvements; well-tolerated with mostly injection-site reactions.
4. Tung et al. (2025) PMC review: Comprehensive mechanism (cardiolipin binding, ROS reduction, ATP restoration); potential in heart failure, neurodegeneration, and aging.
5. Karaa et al. (2023) MMPOWER-3 Phase 3: Safety confirmed but missed primary endpoints in primary mitochondrial myopathy (well-tolerated overall).
8. Swolverine / clinical summaries (2025-2026): Mitochondrial protection, dosing (1–40 mg), and exceptional safety profile.
9. Johns Hopkins / IRCM updates (2025-2026): Co-discovery and real-world Barth syndrome improvements in strength and quality of life.
10. Paragon Sports Medicine / research overviews (2026): Exceptional safety; minimal systemic toxicity; 1-40 mg daily range.

Important disclaimer upfront: SS-31 (Forzinity) IS FDA-approved (accelerated approval Sept 19, 2025) but only for improving muscle strength in patients with Barth syndrome (a rare mitochondrial disease) who weigh at least 30 kg. All other uses are off-label/experimental and not approved. It requires a prescription and monitoring. It is banned by WADA. Long-term safety beyond approved use is still being studied. Always work with a doctor – this is not medical advice.
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DISCLAIMER!

All products are sold in powder (lyophilized) form and require reconstitution with a suitable diluent for research purposes only. Research supplies (e.g., syringes, bacteriostatic water) are not included and need to be purchased separately. No personal human dosing instructions are provided, only research dosages from clinical studies. We adhere to all local and national (SAHPRA) laws around Research Only Chemical sales. We are not a pharmacy, nor do we promote or provide any advice for human or animal consumption. Please review our terms and conditions carefully before making a purchase on our website.

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