Humanin 10mg

R910,00

Humanin 10mg

Humanin 10mg

Neuroprotection, Oxidative Stress, Toxicity, Inflammation, Metabolic Health, Insulin Sensitivity, Cardiovascular Health.

R910,00

Out of stock

What It Is?

Humanin is a lab-made synthetic version of a naturally occurring 24-amino-acid mitochondrial-derived peptide (MDP) encoded in the mitochondrial 16S rRNA gene. Discovered in 2001 while screening for factors that protect neurons from Alzheimer’s-related toxicity, it acts as a stress-response signal from mitochondria to the rest of the cell. Humanin (and its potent analogs like HNG/S14G) is studied for cytoprotective, neuroprotective, and metabolic effects.

Think of Humanin as your mitochondria’s ’emergency SOS signal’ that protects cells under stress and promotes healthy aging.
How it works (super simple):
– Binds receptors (e.g., FPRL1, CNTFR/WSX-1/gp130) and directly inhibits pro-apoptotic proteins (Bax/Bid) at the mitochondrial membrane.
– Activates survival pathways (STAT3, ERK, AKT), reduces oxidative stress, and improves mitochondrial function/insulin sensitivity.

Main benefits (strongest from preclinical models and human correlations):
– Neuroprotection: shields neurons from amyloid-beta toxicity, oxidative stress, and inflammation; potential in Alzheimer’s, Parkinson’s, and stroke models.
– Metabolic health & insulin sensitivity: improves glucose metabolism, reduces body weight gain in obesity/PCOS models, and enhances exercise adaptations.
– Longevity & health span: correlates with longer lifespan in mice; analogs extend median lifespan and reduce inflammation in midlife treatment studies.
– Bonus signals: cardio protection, anti-inflammatory effects, and support for reproductive/ovarian health in aging models.
In short: It helps cells survive stress and age more gracefully by optimizing mitochondrial signaling – one of the most promising MDPs for anti-aging research.

Humanin shows an excellent short-term safety profile in preclinical and limited human correlation studies — endogenous and generally well-tolerated.
In available data: No major toxicities; effects are context-dependent (beneficial in most stress models).
Mild/rare effects:
– Possible transient metabolic shifts (e.g., mild glucose changes – monitor in diabetics).
– Injection-site irritation (rare).
Bigger caveats:
– Unknown ultra-long-term human effects -no large therapeutic trials; some contexts may promote certain inflammatory or tumor-related pathways (theoretical).
– Sex-dependent responses noted in some models.
Bottom line: Appears very safe at research doses – far cleaner than many synthetic peptides – but human data is still emerging.

Reconstitution, dosage and cycling protocols for research purposes.

Method of Administration: Subcutaneous into fatty tissue.

Reconstitution: 2ml Bac water into single vial. See Reconstitution Guide

Dose: 2mg daily, therefore 20 units or 0.2ml. Use peptide calculator (link) for alternative dosage.

Course: 20 days.

Cycling: Repeat every 3 months for maintenance or as needed (e.g., during respiratory seasons or after illness).

  • Mitochondrial messenger – the first discovered MDP (mitochondrial-derived peptide); encoded in mtDNA and signals to the nucleus during stress.
  • Alzheimer’s discovery – found while hunting for factors that protect surviving brain cells in Alzheimer’s patients.
  • Lifespan link – higher natural levels correlate with longer life in mice; midlife treatment with analog HNG extends health span.
  • 24-amino-acid mini-protein – small but mighty; a potent analog (HNG/S14G) is 1,000× stronger than natural Humanin.
  • Insulin sensitizer – improves glucose metabolism and exercise adaptations without the downsides of full growth hormone.
  • Sex-specific nuances – effects can differ between males and females in some models.
  • Research rising star – still actively studied in 2026 for neurodegeneration, metabolism, and healthy aging.

Human data is mostly correlative (levels in aging/AD); strongest evidence is preclinical (mice, cells) with promising longevity/metabolic signals.
1. Coradduzza et al. (2023 PMC): Comprehensive review – Humanin improves glucose/insulin sensitivity in animal models; links to aging, metabolism, and cytoprotection.
2. The Peptide Catalog (Feb 2026): Dosing guide — 100–300 mcg research range; mechanisms (Bax/Bid inhibition, STAT3 activation); longevity protocols.
3. Swolverine (Jul 2025): Beginner guide – neuroprotective, metabolic, and anti-aging benefits; safe endogenous peptide.
4. ScienceDirect overview: Protective effects in neurons, leukocytes, gonadal cells; stress resistance and potential in neurodegeneration.
5. Peptide Calculator App (Dec 2025): Dosage/mechanism – insulin sensitivity, neuroprotection; 100–1000 mcg ranges in research.
6. Yen et al. (2013 PMC): Emerging role in stress resistance; cytoprotective against oxidative stress, hypoxia, etc.
7. Aging-US (Jun 2020): Humanin regulates lifespan/healthspan in mice; midlife HNG treatment improves metabolic parameters and reduces inflammation.
8. Paragon Sports Medicine (2026): Energy & healthy aging — mitochondrial optimization, cellular protection; research-only status.
9. Alzheimer’s Drug Discovery Foundation (updated references): Evidence summary – neuroprotective in AD models; insulin sensitivity and healthspan benefits; no human therapeutic trials yet.
10. ResearchGate / lifespan study (Dec 2025 update): Midlife HNG extends healthspan and lifespan in mice; first demonstration of MDP regulating longevity.

Takeaway: Strong preclinical longevity/neuroprotection data + human correlations; we need large clinical trials for therapeutic validation.

Important disclaimer upfront: Humanin is NOT approved by the FDA (or any major Western agency) as of 2026. It remains strictly investigational/research chemical in the US (compounded versions face restrictions under 2026 peptide rules). It is approved and widely used in Russia as a prescription medication for immune restoration. Long-term safety data in healthy Western populations is limited. It is banned by WADA. Always talk to a doctor – this is not medical advice.
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DISCLAIMER!

All products are sold in powder (lyophilized) form and require reconstitution with a suitable diluent for research purposes only. Research supplies (e.g., syringes, bacteriostatic water) are not included and need to be purchased separately. No personal human dosing instructions are provided, only research dosages from clinical studies. We adhere to all local and national (SAHPRA) laws around Research Only Chemical sales. We are not a pharmacy, nor do we promote or provide any advice for human or animal consumption. Please review our terms and conditions carefully before making a purchase on our website.

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